Atypical spindle cell osteosarcoma in the diaphysis and proximal epiphysis of the tibia: clinical case report

Authors

  • Juan Miranda-Pacheco University of Sinú Elías Bechara Zainum https://orcid.org/0000-0001-6422-0385 (unauthenticated)
  • Jorge Salim Abuchar-Vásquez University of Sinú Elías Bechara Zainum
  • Valentina Salgado-Espitia University of Sinú Elías Bechara Zainum
  • William Andrés Zabala-Aparicio University of Sinú Elías Bechara Zainum
  • Karina Pastor-Sierra University of Sinú Elías Bechara Zainum

DOI:

https://doi.org/10.33975/riuq.vol35n1.898

Keywords:

neoplasia, sarcoma, diaphysis, epiphysis

Abstract

Osteosarcoma is the most common primary malignant tumor of the bone, characterized by the formation of osteoid from tumor cells. Its most common location is in the metaphysis of the long bones; however, the proximal part of the tibia is one of the most frequent, with 50% to 60% of cases. The aim of this work is to describe a case study of a male patient diagnosed with spindle cell osteosarcoma, who presented signs and symptoms three months prior to evaluation, secondary to localized trauma to his lower limb. From the imaging point of view, an image suggestive of a metaphyseal tumor lesion that extended to the epiphysis and the medullary canal was observed. The histopathological and imaging study concluded that the patient had a grade II spindle cell osteosarcoma in the right proximal tibia, which required surgical management and chemotherapy with a good clinical response. The importance of scientific and biomedical advances is evident, which have allowed a better management of these diseases and a treatment that generates better conditions for post-surgical rehabilitation and life expectancy.

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Author Biographies

  • Juan Miranda-Pacheco, University of Sinú Elías Bechara Zainum

    Docente Ciencias Básicas de la Salud 

  • Jorge Salim Abuchar-Vásquez, University of Sinú Elías Bechara Zainum

    Médico general 

  • Valentina Salgado-Espitia, University of Sinú Elías Bechara Zainum

    Médico general 

  • William Andrés Zabala-Aparicio, University of Sinú Elías Bechara Zainum

    Médico general 

References

Durfee RA, Mohammed M, Luu HH. Review of osteosarcoma and current management. Rheumatology therapy. 2016;3(2):221-43.

López AA, Lorenzo YG, Álvarez AP, Lorenzo MG. Osteosarcoma: enfoque actual. Archivo Médico Camagüey. 2014;14(5).

Mirabello L, Troisi RJ, Savage SA. International osteosarcoma incidence patterns in children and adolescents, middle ages and elderly persons. International journal of cancer. 2009;125(1):229-34.

Zhang J, Walsh MF, Wu G, Edmonson MN, Gruber TA, Easton J, et al. Germline mutations in predisposition genes in pediatric cancer. New England Journal of Medicine. 2015;373(24):2336-46.

Coventon J. A review of the mechanism of action and clinical applications of sorafenib in advanced

Clayer M. Many faces of osteosarcoma on plain radiographs. ANZ journal of surgery. 2015;85(1-2):22-6.

Harper K, Sathiadoss P, Saifuddin A, Sheikh A. A review of imaging of surface sarcomas of bone. Skeletal Radiology. 2020:1-20.

Barros G, Trujillo ÁM, Jaramillo L, Ortiz FH, Contreras AD. Malignant bone tumors in Pediatrics. Five year experience in a pediatric referral center. Revista de la Facultad de Medicina. 2016;64(3):403-7.

Chen EL, Yoo CH, Gutkin PM, Merriott DJ, Avedian RS, Steffner RJ, et al. Outcomes for pediatric patients with osteosarcoma treated with palliative radiotherapy. Pediatric blood cancer epidemiology. 2020;67(1):e27967.

Camuzard O, Santucci-Darmanin S, Carle GF, Pierrefite-Carle V. Role of autophagy in osteosarcoma. Journal of bone oncology. 2019;16:100235.

De Armas L, Delgado D, Alvarado K, Cordero C. Osteosarcoma: Etiología, diagnóstico y tratamiento. Revista Clínica de la Escuela de Medicina de la Universidad de Costa Rica. 2018;8(4):1-5.

Hashimoto K, Nishimura S, Oka N, Akagi M. Outcomes of comprehensive treatment for primary osteosarcoma. SAGE Open Medicine. 2020;8: 2050312120923177.

Marulanda GA, Henderson ER, Johnson DA, Letson GD, Cheong D. Orthopedic surgery options for the treatment of primary osteosarcoma. Cancer Control. 2008;15(1):13-20.

Harrison DJ, Schwartz CL. Osteogenic sarcoma: systemic chemotherapy options for localized disease. Current treatment options in oncology. 2017;18(4):24.

Jeys L, Kulkarni A, Grimer R, Carter S, Tillman R, Abudu A. Endoprosthetic reconstruction for the treatment of musculoskeletal tumors of the appendicular skeleton and pelvis. JBJS. 2008;90(6):1265-71.

Schwartz AJ, Kabo JM, Eilber FC, Eilber FR, Eckardt JJ. Cemented distal femoral endoprostheses for musculoskeletal tumor: improved survival of modular versus custom implants. Clinical Orthopaedics Related Research. 2010;468(8):2198-210.

Grimer R, Aydin B, Wafa H, Carter S, Jeys L, Abudu A, et al. Very long-term outcomes after endoprosthetic replacement for malignant tumours of bone. The bone joint journal. 2016;98(6):857-64

Published

2023-04-05

Issue

Section

Original Article

How to Cite

Atypical spindle cell osteosarcoma in the diaphysis and proximal epiphysis of the tibia: clinical case report. (2023). Revista De Investigaciones Universidad Del Quindío, 35(1), 36-42. https://doi.org/10.33975/riuq.vol35n1.898